韩亚平 现任职称/职务：讲师，硕导 通讯地址：天津市北辰区河北工业大学3308维多利亚检测线路B305 邮政编码：300401 电子邮箱：2019070@hebut.edu.cn 联系电话：（13212270268） |
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研究领域 |
1.有机电合成 2.有机合成方法学 3.过渡金属催化 |
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讲授课程 |
《药物合成反应》、《高等有机化学》、《天然药物化学》、《药物分析实验》 |
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学术经历 |
2014-09-2019-06 兰州大学硕博连读 2019-07-至今 河北工业大学任教 |
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学术兼职 |
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学术成就 |
学术成就: 工作集中于有机合成化学中新方法、新策略研究，具体工作涵盖电促金属催化碳氢键官能团化、路易斯酸或布朗斯特酸催化炔丙醇串联反应、钯催化卤代吲哚Heck脱芳构化反应等多个领域，以药物小分子骨架的高效合成为主。迄今为止，申请人在重要学术期刊（Nat. Commun., Chin. J. Catal., Org. Lett.等）发表SCI论文50余篇，以通讯作者或第一作者发表SCI论文30篇，其中SCI二区及以上论文22篇，包括Chin. J. Catal. 1篇，Org. Lett. 2篇，J. Org. Chem. 7篇，Adv. Synth. Catal. 8篇，Chin. J. Chem. 1篇，Org. Chem. Front. 2篇等。近五年代表性论文情况如下： 1. Yun-Zhao Wang, Bing Sun, Jian-Feng Guo, Xiao-Yu Zhu, Yu-Cheng Gu, Ya-Ping Han, Cong Ma, Tian-Sheng Mei, Enantioselective Reductive Cross-Couplings to Forge C(sp2)-C(sp3) Bonds by Merging Electrochemistry with Nickel Catalysis, Nat. Commun. 2025, 16, 1108-1108 (SCI 一区). 2. Ning-Yu Guo (本科生), Xiao-Yi Cheng, Xiao-Dan Dong, Chun-e Peng, Chun Zhang, Ya-Ping Han,* and Li-Zeng Peng, New Synthetic Approaches for the Construction of 2-Aminophenoxazinone Architectures, RSC Adv. 2025, 15, 9479–9509 (SCI 三区). 3. Zhou Sun, Xue-Song Zhang (本科生),* Shao-Wei Bian,* Chun Zhang, Ya-Ping Han,* Yong-Min Liang, New Synthetic Approaches for the Construction of Difluoromethylated Architectures, Org. Biomol. Chem. 2025, 23, 3029–3075 (SCI 三区). 4. Qing-Hui Liu, Jiaxuan Liu, Ya-Ping Han,* Yong-Min Liang, Li-Zeng Peng*, Synthetic Approaches for the Construction of Chiral Aziridines, Eur. J. Org. Chem., 2025, 28, e202401048 (SCI 三区). 5. Yi-Fan Xi, Rui-Xing Gao, Ping Fang, Ya-Ping Han,* Cong Ma, Tian-Sheng Mei,* Siteselective Benzylic C-H Oxidation through Mediated Electrolysis, Chinese J Catal, 2024, 67, 54-60 (SCI 一区). 6. Zhou Sun, Jia-Xuan Liu (本科生), Lin Shi, Ming Yang, Yuan Wang, Ya-Ping Han,* Xiaojun Yao*, and Yong-Min Liang. New Synthetic Approaches for the Construction of Enantioenriched Molecules Bearing Quaternary Stereocenters. Adv. Synth. Catal. 2024, 366, 4294−��������4322 (SCI 二区). 7. Xiang Li (本科生), Ning-Yu Guo, Qing-Hui Liu, Ya-Ping Han,* Hong-Yu Zhang,* and Li-Zeng Peng*. Lewis Acid-Catalyzed Tandem Annulation of Propargylic Alcohols with 2-Allylphenols and Their Anti-tumor Activities. Asian J. Org. Chem. 2024, e202400265 (SCI 三区). 8. Jia-Xuan Liu (本科生), Sheng-Qi Xu, Ya-Ping Han,* Yong-Min Liang; Recent Advances in Cyclization Reactions of 1,6-Enynes. Adv. Synth. Catal. 2024, 366, 1220−��������1268 (SCI 二区). 9. Qing-Hui Liu, Yue Ma, Hong-Yu Zhang, Yuecheng Zhang, * Jiquan Zhao, Xiaohui Cao,* Ya-Ping Han,* and Yong-Min Liang; Experimental and Computational Studies on the Palladium-catalyzed Intramolecular Dearomatization, Electrophilic Addition, Intermolecular Coupling Sequence. Org. Chem. Front. 2024, 11, 1357-1365 (SCI 一区TOP). 10. Xue-Song Zhang (本科生), Ya-Ping Han,* Yong-Min Liang; Recent Advances in the Cascade Cyclization Reactions of 1,7-Enynes. Adv. Synth. Catal. 2024, 366, 324−��������356 (SCI 二区). 11. Peng Liu, Hongyu Zhang, Yaping Han, Jiquan Zhao, Yuecheng Zhang,* Pore Size-Tunable Core-Shell Structured Ni-Ru Nanoparticles Catalyst for the Reductive Amination of Isosorbide Diketone, Chem. Eng. J. 2023, 476, 146820 (SCI 一区). 12. Zhao-Nan Cai, Ya-Ping Han, Yuecheng Zhang, Hong-Yu Zhang, Jiquan Zhao and Shang-Dong Yang, Metal-Free Direct C–H Phosphonation of N-Heterocycles with Diphenylphosphine Oxides under Mild Conditions, Green Chem. 2023, 25, 5721−��������5726 (SCI 一区). 13. Xi-Yan Ren (本科生), Xiang-Xuan Feng, Hong-Yu Zhang, Yuecheng Zhang,* Jiquan Zhao, Ya-Ping Han,* Yong-Min Liang; Lewis Acid Catalyzed [4 + 2] Annulation of Propargylic Alcohols with 2-Vinylanilines. J. Org. Chem. 2023, 88, 16007−��������16017 (SCI 二区TOP). 14. Yue Ma, Qing-Hui Liu, Ya-Ping Han,* Palladium-Catalyzed Enantioselective Intramolecular Heck Dearomative Annulation of Indoles with N‑��������Tosylhydrazones. J. Org. Chem. 2023, 88, 15881−��������15893 (SCI 二区TOP). 15. Xue-Song Zhang (本科生), Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, Transition-Metal-Catalyzed Transformations Involving the Heck Reaction. Adv. Synth. Catal. 2023, 365, 2436–2466 (SCI 二区). 16. Bo-Ya Hao (本科生), Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, New Synthetic Approaches toward OCF3-Containing Compounds. Org. Biomol. Chem. 2023, 21, 4926–4954 (SCI 三区). 17. Shao-Bo Duan, Hong-Yu Zhang, Yue Ma, Jiquan Zhao, Ya-Ping Han,* Yuecheng Zhang,* and Yong-Min Liang, Palladium-Catalyzed Intramolecular Heck Dearomative Alkenylation of Indoles with N‑��������Tosylhydrazones. J. Org. Chem. 2022, 87, 10917−��������10927 (SCI 二区TOP). 18. Zhao-Nan Cai, Xiang-Xuan Feng, Yuecheng Zhang, Cong-Cong Lu, Ya-Ping Han,* Jiquan Zhao*, Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols. Chin. J. Chem. 2022, 40, 71−��������78 (SCI 一区). 19. Cong-Cong Lu, Bo-Ya Hao, Ya-Ping Han,* and Yong-Min Liang*, Recent Advances in the Synthesis of Indolines via Dearomative Annulation of N-acylindoles. Asian J. Org. Chem. 2022, 11, 10, e202200312 (SCI 三区). 20. Yuanfeng Li; Hong-Yu Zhang; Yuecheng Zhang; Ya-Ping Han*; Jiquan Zhao*; Yong-Min Liang; Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines, J. Org. Chem, 2021, 86, 14640-14651 (SCI 二区TOP). 21. Duan, Shao-Bo; Zhang, Hong-Yu; Hao, Bo-Ya; Zhao, Jiquan; Han, Ya-Ping*; Zhang, Yuecheng; Liang*, Yong-Min; Palladium-catalyzed intramolecular diastereoselective dearomatization reaction of indoles with N-tosylhydrazones, Org. Chem. Front. 2021, 8, 5895-5901 (SCI 一区TOP). 22. Shao-Bo Duan, Xu-Jing Gao, Hong-Yu Zhang, Cong-Cong Lu, Jiquan Zhao, Ya-Ping Han*, Yuecheng Zhang*, Yong-Min Liang*. Palladium-Catalyzed Intramolecular Tandem Dearomatization of Indoles for the Synthesis of Tetracyclic Indolines, Arab. J. Chem. 2021, 14, 103155 (SCI 二区). 23. Yuanfeng Li, Yue-Su, Hong-Yu Zhang, Yuecheng Zhang, Dong-Han, Ya-Ping Han,* Jiquan Zhao,* and Yong-Min Liang; Synthesis of Tetracyclic Indolines through Palladium‐Catalyzed Asymmetric Dearomative reaction of Aryl Iodides, ChemistrySelect. 2021, 6, 4719 –4724 (SCI 四区). 奖励及荣誉： |
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科研项目 |
[1] 中央引导地方项目，2025ZY-QYCXYL-16，秦巴山区杜仲天然产物的三氟甲基化方法开发及在治疗三阴性乳腺癌中的探究，2025-01-01至2027-12-31，20万，在研，主持。 [2] 光学活性[6,5,5,6]含氮四环化合物及系列含氟化合物的开发，济南盛石生物医药科技有限公司，2025-10-25至2027-10-24，合同经费180万元，到校经费100万元，在研，主持。 [3] 国家自然科学基金委员会，国际(地区)合作与交流项目，W2512056，面向有机分子编辑的仿生过渡金属配合物到COFs基纳米酶新型催化材料，2026-01-01至2028-12-31，150万元，在研，参与。 [4] [5,6,5]含氧三环化合物及其衍生物的开发，天津卡普希科技有限公司，2024-11-20至2026-11-19，合同经费10万元，到校经费10万元，在研，主持。 [5] 河北省自然科学基金，面上项目，B2024202006，三氟甲氧基自由基参与炔烃化合物串联反应研究，2024-01至2026-12，6万，在研，主持。 [6] 光学活性吲哚啉化合物及其衍生物的开发，淄博百极荣创医药科技有限公司，2024-6-4至2026-6-3，合同经费30万元，到校经费3万元，在研，主持。 [7] 河北省教育厅科学基金委员会，重点项目，ZD2021026，三氟甲氧基自由基参与炔烃串联反应构建烯基三氟甲氧基类化合物，2021-01至2023-12，10万，结题，主持。 [8] 河北省自然科学基金委员会，青年基金项目，B2020202010，基于炔丙基类衍生物的串联反应研究，2020-01至2022-12，结题，主持。 [9] 国家自然科学基金委员会，面上项目，21772075，基于丙炔醇的若干新颖串联反应研究，2018-01至2021-12，结题，64万，参与。 |
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论著专利 |
[1] 路易斯酸催化炔丙醇合成[5,6,5]含氧三环化合物及其制备方法，韩亚平,刘庆辉,李响,张雪松,刘嘉璇，已申请，申请号：2024104658146，申请日期：2024.04.18。 [2] 钯催化吲哚分子内脱芳构化合成吲哚啉喹啉衍生物及其制备方法，韩亚平,马岳,刘庆辉，已申请，申请号：2023114912581，申请日期：2023.11.10。 [3] 路易斯酸催化炔丙醇合成喹啉衍生物及其制备方法，韩亚平,李响,任喜燕,封向璇，已申请，申请号：2023110270167，申请日期：2023.08.16。 |
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招生方向 |
化学工程/化学工程与设计/生物技术与工程 |
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